Cart
sales@molnova.com
AZD-9291 dimesylate
CAS No.
AZD-9291 dimesylate ( Osimertinib dimesylate;Mereletinib dimesylate )
Catalog No. M16969 CAS No.
A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAZD-9291 dimesylate
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
-
DescriptionA potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively; weak activity against wt EGFR (IC50=184 nM); inhibits signaling pathways and cellular growth in both EGFRm(+) and EGFRm(+)/T790M(+) mutant cell lines in vitro; exhibits tumor regression in EGFR-mutant tumor xenograft and transgenic models; orally active.Lung Cancer Approved
-
SynonymsOsimertinib dimesylate;Mereletinib dimesylate
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number--
-
Formula Weight691.82
-
Molecular FormulaC30H41N7O8S2
-
Purity>98% (HPLC)
-
SolubilityDMSO: 0.4 mg/mL
-
SMILES——
-
Chemical Name2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:2)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Finlay MR, et al. J Med Chem. 2014 Oct 23;57(20):8249-67.
2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61.
3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61.
3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
molnova catalog
related products
-
Genistein
Genistein(NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
-
Desmethyl Erlotinib
OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
-
5-Iodotubercidin
5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
