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AZD-9291 dimesylate
CAS No.
AZD-9291 dimesylate ( Osimertinib dimesylate;Mereletinib dimesylate )
Catalog No. M16969 CAS No.
A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAZD-9291 dimesylate
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively.
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DescriptionA potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively; weak activity against wt EGFR (IC50=184 nM); inhibits signaling pathways and cellular growth in both EGFRm(+) and EGFRm(+)/T790M(+) mutant cell lines in vitro; exhibits tumor regression in EGFR-mutant tumor xenograft and transgenic models; orally active.Lung Cancer Approved
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SynonymsOsimertinib dimesylate;Mereletinib dimesylate
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight691.82
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Molecular FormulaC30H41N7O8S2
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Purity>98% (HPLC)
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SolubilityDMSO: 0.4 mg/mL
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SMILES——
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Chemical Name2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Finlay MR, et al. J Med Chem. 2014 Oct 23;57(20):8249-67.
2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61.
3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
2. Cross DA, et al. Cancer Discov. 2014 Sep;4(9):1046-61.
3. Eberlein CA, et al. Cancer Res. 2015 Jun 15;75(12):2489-500.
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